Altered function in atrium of transgenic mice

Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice.

Weak antioxidant capacity, particularly low catalase activity in the heart, may be a factor responsible for the high sensitivity of this organ to doxorubicin-induced oxidative damage. To test this hypothesis, a heart-specific promoter was used to drive the expression of murine catalase cDNA in transgenic mice. Fifteen healthy transgenic mouse lines were produced. Cardiac catalase activity was c...

New insights in pathophysiology of contact hypersensitivity: From transgenic mice to human pathology

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Genetically modified mice- Methods, applications and outlook

Background & Aim: Transgenic mice, of tengenerated by random integration of foreign genes into the mouse genome or by targeted mutation in a particular gene, have demonstrated to be a very effective tool for studying gene function in living things. In this review article, we discussed on the current methods of generating genetically-modified mice and their related problems and then investigated...

I-43: Identification of SOX3 as an XX MaleSex Reversal Gene in Mice and Jumans

Background: Mammals utilise an XX/XY system of sex determination in which the Y-linked gene SRY (Sexdetermining region Y) exerts a dominant masculinising influence on sexual development. Sex chromosome homology and comparative sequence studies suggest that SRY evolved from the related SOX3 gene on the X chromosome, although there is no direct functional evidence to support this hypothesis. The ...

Development of Transgenic Mice Harboring Ovine Beta Lactoglobulin-Calcitonin Transgene